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ska121  (MedChemExpress)
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MedChemExpress ska121
Effects of K Ca 3.1 activation and LRRC8A inhibition on CCL2 expression and secretion in M 2 -MACs. ( A , B ): Real-time PCR examination of CCL22 ( A ) and CCL2 ( B ) expression in native THP-1 cells (native) and M 2 -MACs (M 2 ) ( n = 4). Data are normalized to ACTB. ( C , D , F , G ): Real-time PCR examination of CCL22 ( C , F ) and CCL2 ( D , G ) expression following treatment with vehicle, 10 μM <t>SKA121</t> (SKA) ( C , D ), or 10 μM endovion (EDV) ( F , G ) for 12 h in M 2 -MACs ( n = 4). Expression levels are normalized to ACTB and shown relative to vehicle control (set as 1.0). ( E , H ): ELISA quantification of CCL2 secretion after 24 h treatment with SKA ( E ) or EDV ( H ) in M 2 -MACs ( n = 4). Secretion levels are shown relative to vehicle control (set as 1.0). **: p < 0.01 vs. native THP-1 or vehicle control.
Ska121, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 93 stars, based on 1 article reviews
ska121 - by Bioz Stars, 2026-03
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ska 121  (MedChemExpress)
93
MedChemExpress ska 121
Effects of K Ca 3.1 activation and LRRC8A inhibition on CCL2 expression and secretion in M 2 -MACs. ( A , B ): Real-time PCR examination of CCL22 ( A ) and CCL2 ( B ) expression in native THP-1 cells (native) and M 2 -MACs (M 2 ) ( n = 4). Data are normalized to ACTB. ( C , D , F , G ): Real-time PCR examination of CCL22 ( C , F ) and CCL2 ( D , G ) expression following treatment with vehicle, 10 μM <t>SKA121</t> (SKA) ( C , D ), or 10 μM endovion (EDV) ( F , G ) for 12 h in M 2 -MACs ( n = 4). Expression levels are normalized to ACTB and shown relative to vehicle control (set as 1.0). ( E , H ): ELISA quantification of CCL2 secretion after 24 h treatment with SKA ( E ) or EDV ( H ) in M 2 -MACs ( n = 4). Secretion levels are shown relative to vehicle control (set as 1.0). **: p < 0.01 vs. native THP-1 or vehicle control.
Ska 121, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ska 121/product/MedChemExpress
Average 93 stars, based on 1 article reviews
ska 121 - by Bioz Stars, 2026-03
93/100 stars
  Buy from Supplier
ska-121  (Wulff labs)
90
Wulff labs ska-121
Effects of K Ca 3.1 activation and LRRC8A inhibition on CCL2 expression and secretion in M 2 -MACs. ( A , B ): Real-time PCR examination of CCL22 ( A ) and CCL2 ( B ) expression in native THP-1 cells (native) and M 2 -MACs (M 2 ) ( n = 4). Data are normalized to ACTB. ( C , D , F , G ): Real-time PCR examination of CCL22 ( C , F ) and CCL2 ( D , G ) expression following treatment with vehicle, 10 μM <t>SKA121</t> (SKA) ( C , D ), or 10 μM endovion (EDV) ( F , G ) for 12 h in M 2 -MACs ( n = 4). Expression levels are normalized to ACTB and shown relative to vehicle control (set as 1.0). ( E , H ): ELISA quantification of CCL2 secretion after 24 h treatment with SKA ( E ) or EDV ( H ) in M 2 -MACs ( n = 4). Secretion levels are shown relative to vehicle control (set as 1.0). **: p < 0.01 vs. native THP-1 or vehicle control.
Ska 121, supplied by Wulff labs, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ska-121/product/Wulff labs
Average 90 stars, based on 1 article reviews
ska-121 - by Bioz Stars, 2026-03
90/100 stars
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ska-121  (Millipore)
90
Millipore ska-121
TABLE 1
Ska 121, supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ska-121/product/Millipore
Average 90 stars, based on 1 article reviews
ska-121 - by Bioz Stars, 2026-03
90/100 stars
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Effects of K Ca 3.1 activation and LRRC8A inhibition on CCL2 expression and secretion in M 2 -MACs. ( A , B ): Real-time PCR examination of CCL22 ( A ) and CCL2 ( B ) expression in native THP-1 cells (native) and M 2 -MACs (M 2 ) ( n = 4). Data are normalized to ACTB. ( C , D , F , G ): Real-time PCR examination of CCL22 ( C , F ) and CCL2 ( D , G ) expression following treatment with vehicle, 10 μM SKA121 (SKA) ( C , D ), or 10 μM endovion (EDV) ( F , G ) for 12 h in M 2 -MACs ( n = 4). Expression levels are normalized to ACTB and shown relative to vehicle control (set as 1.0). ( E , H ): ELISA quantification of CCL2 secretion after 24 h treatment with SKA ( E ) or EDV ( H ) in M 2 -MACs ( n = 4). Secretion levels are shown relative to vehicle control (set as 1.0). **: p < 0.01 vs. native THP-1 or vehicle control.

Journal: International Journal of Molecular Sciences

Article Title: Transcriptional Repression of CCL2 by K Ca 3.1 K + Channel Activation and LRRC8A Anion Channel Inhibition in THP-1-Differentiated M 2 Macrophages

doi: 10.3390/ijms26157624

Figure Lengend Snippet: Effects of K Ca 3.1 activation and LRRC8A inhibition on CCL2 expression and secretion in M 2 -MACs. ( A , B ): Real-time PCR examination of CCL22 ( A ) and CCL2 ( B ) expression in native THP-1 cells (native) and M 2 -MACs (M 2 ) ( n = 4). Data are normalized to ACTB. ( C , D , F , G ): Real-time PCR examination of CCL22 ( C , F ) and CCL2 ( D , G ) expression following treatment with vehicle, 10 μM SKA121 (SKA) ( C , D ), or 10 μM endovion (EDV) ( F , G ) for 12 h in M 2 -MACs ( n = 4). Expression levels are normalized to ACTB and shown relative to vehicle control (set as 1.0). ( E , H ): ELISA quantification of CCL2 secretion after 24 h treatment with SKA ( E ) or EDV ( H ) in M 2 -MACs ( n = 4). Secretion levels are shown relative to vehicle control (set as 1.0). **: p < 0.01 vs. native THP-1 or vehicle control.

Article Snippet: EDV (HY-105917), SKA121 (HY-107414), SP600125 (HY-12041), and PD169316 (HY-10578) were from MedChemExpress (Monmouth Junction, NJ, USA).

Techniques: Activation Assay, Inhibition, Expressing, Real-time Polymerase Chain Reaction, Control, Enzyme-linked Immunosorbent Assay

TABLE 1

Journal: Molecular Pharmacology

Article Title: New Positive Ca 2+ -Activated K + Channel Gating Modulators with Selectivity for K Ca 3.1

doi: 10.1124/mol.114.093286

Figure Lengend Snippet: TABLE 1

Article Snippet: Preparation and injection of SKA-111 and SKA-121 were as follows: Appropriate amounts of SKA-111 and SKA-121 were dissolved in warmed peanut oil (SKA-111) or in a mixture of peanut oil/DMSO (9:1 v/v, both from Sigma-Aldrich DK) to give a dose of 30 or 100 mg/kg.

Techniques: